Interference of Progestins With Endothelial Actions of Estrogens
نویسندگان
چکیده
منابع مشابه
Estrogens, progestins, and atherosclerosis.
To the Editor: We feel compelled to comment on the Brief Review “Should progestins be blamed for the failure of hormone replacement therapy to reduce cardiovascular events in randomized controlled trials?” by Koh and Sakuma.1 Specifically, although we agree with the suggestion that the effects of estrogen on the vasculature may depend on the extent and severity of existing atherosclerosis, we d...
متن کاملEstrogens, Progestins, and Atherosclerosis
To the Editor: We feel compelled to comment on the Brief Review “Should progestins be blamed for the failure of hormone replacement therapy to reduce cardiovascular events in randomized controlled trials?” by Koh and Sakuma.1 Specifically, although we agree with the suggestion that the effects of estrogen on the vasculature may depend on the extent and severity of existing atherosclerosis, we d...
متن کاملEstrogens, Progestins, and Atherosclerosis
To the Editor: We feel compelled to comment on the Brief Review “Should progestins be blamed for the failure of hormone replacement therapy to reduce cardiovascular events in randomized controlled trials?” by Koh and Sakuma.1 Specifically, although we agree with the suggestion that the effects of estrogen on the vasculature may depend on the extent and severity of existing atherosclerosis, we d...
متن کاملEstrogens, progestins, and heart disease: can endothelial function divine the benefit?
Coronary atherosclerosis is a prevalent, preventable, but slow disease. Demonstrating the clinical effect of an intervention requires at least 3 to 5 years, even in high-risk populations. Despite considerable supportive observational data, the value of hormone replacement therapy in the treatment of coronary heart disease in postmenopausal women remains uncertain. It is therefore very attractiv...
متن کاملEstrogens, Progestins, and Specific Estrogen Receptor Modulators (SERMs)
Biologically important natural estrogens and progestins include estradiol, estrone, estriol, and progesterone. Estradiol-17 is the most potent estrogen that is found naturally in women. Estrone is one-tenth as biologically active as estradiol, and estriol is the weakest of the three. Estriol is synthesized by the placenta and is excreted at high levels in the urine of pregnant women. Progestero...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2009
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.108.182337